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Kimura, S.; Kameyama, K.; Hosoi, E.; Saito, S.
Nihon Naibunpi Gakkai Zasshi 65(2): 113-127
1989
ISSN/ISBN: 0029-0661 PMID: 2568278 DOI:10.1507/endocrine1927.65.2_113Accession:041636501
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Summary
The effects of prostaglandin E2 (PGE2), 2-deoxy-D-glucose (2-DG) and L-arginine on hypothalamic GHRH and SRIF release with respect to GH secretion were studied in conscious male rats. Intracerebroventricular (icv) injection of 5 micrograms PGE2 and intravenous (iv) infusion of 1 g/kgBW L-arginine caused an increase in plasma GH levels, but icv (36 micrograms) or iv (400 mg/kgBW) injection of 2-DG suppressed spontaneous GH surge in conscious rats. The concentration of hypothalamic GHRH was decreased in all three groups of the animals, but the concentration of hypothalamic SRIF was decreased only in 2-DG-treated animals. In the perifusion system using rat hypothalamus, PGE2 (0.28 microM, 2.8 microM), 2-DG (22 mM) and L-arginine (3 mM) stimulated GHRH release from rat hypothalamus. 2-DG also stimulated SRIF release more predominantly than GHRH release. Passive immunization with anti-GHRH serum inhibited the GH secretion induced by icv injection of 5 micrograms PGE2 and by iv infusion of 1 g/kgBW L-arginine in conscious rats. In contrast, GH secretion induced by iv injection of 50 micrograms/kgBW PGE2 was not affected by the pretreatment with the antiserum. These results suggest that the central effect of PGE2 and peripheral effect of L-arginine to stimulate GH secretion are mediated by hypothalamic GHRH release, and that the inhibitory effect of 2-DG on GH secretion is predominantly mediated by hypothalamic SRIF release rather than GHRH release in rats.References
Rossowski, W.J.; Cheng, B.L.; Coy, D.H. 1998: New potent somatostatin receptor 2 antagonist inhibits SRIF and SRIF-mediated effects on pentagastrin-stimulated gastric acid secretion in conscious rats Gastroenterology 114(4 Part 2): A1175
Mitsugi, N. 1988: Studies on the hypothalamic regulation of the secretion on somatostatin srif and growth hormone releasing factor ghrf the effects of intraventricular administration on ghrf and srif in the hypophyseal portal blood Yokohama Medical Journal 39(4): 231-240
Stratakis, C.A.; Chrousos, G.P. 1997: Hypothalamic hormones GnRH, TRH, GHRH, SRIF, CRH, and dopamine Pizzo, P A , Poplack, D G Principles and practice of pediatric oncology, Third edition : 947-976
Stachura, M.E.; Tyler, J.M.; Farmer, P.K. 1988: Combined effects of human growth hormone (GH)-releasing factor-44 (GRF) and somatostatin (SRIF) on post-SRIF rebound release of GH and prolactin: a model for GRF-SRIF modulation of secretion Endocrinology 123(3): 1476-1482
Al-Barazanji, K.A.; Wilson, S.; Baker, J.; Jessop, D.S.; Harbuz, M.S. 2001: Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious rats Journal of Neuroendocrinology 13(5): 421-424
Chaleek, N.; Kermani, M.; Eliassi, A.; Haghparast, A. 2012: Effects of orexin and glucose microinjected into the hypothalamic paraventricular nucleus on gastric acid secretion in conscious rats Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society 24(2): E94-102
Miell, J.; Corder, R.; Pralong, F.; Gaillard, R. 1990: Effects of dexamethasone on dopaminergic ghrh and arginine stimulated gh secretion Neuroendocrinology 52(Suppl 1): 125
Wang Y X.; Zhou, T.; Pang, C.C.Y. 1991: Pressor effects of l and d enantiomers of n g nitro arginine in conscious rats are antagonized by l arginine but not d arginine European Journal of Pharmacology 200(1): 77-82
Starcevic, V.; Balaban, C.D.; Severs, W.B. 1988: Effects of arginine vasopressin avp on somatostatin srif induced barrel rotation br and convulsions in rats Society for Neuroscience Abstracts 14(1): 267
Maghnie, M.; Moretta, A.; Valtorta, A.; Preti, P.; Palladini, G.; Zuliani, I.; Larizza, D.; Severi, F. 1993: Effects of continuous GHRH infusion of GH secretion in GH-deficient patients with hypothalamic-pituitary abnormalities Pediatric Research 33(5 Suppl): S30
Sato, T.; Igarashi, N.; Miyagawa, K.; Shimizu, M.; Nishikawa, T.; Hashimoto, T. 1990: Mutual priming effects of GHRH and arginine on GH secretion: informative procedure for evaluating GH secretory dynamics Endocrinologia Japonica 37(4): 501-509
Sato, T.; Igarashi, N.; Miyagawa, K.; Shimizu, M.; Nishikawa, T.; Hashimoto, T. 1990: Mutual priming effects of GHRH and arginine on GH secretion: informative procedure for evaluating GH secretory dynamics Endocrinologia Japonica 37(4): 501-509
Arvat, E.; Gianotti, L.; Grottoli, S.; Imbimbo, B.P.; Lenaerts, V.; Deghenghi, R.; Camanni, F.; Ghigo, E. 1994: Effects of hexarelin, a synthetic hexapeptide, alone and combined with GHRH or arginine on GH secretion in normal elderly subjects Neuroendocrinology 60(Suppl 1): 32
Bellone, J.; Valetto, M.R.; Aimaretti, G.; Segni, M.; Volta, C.; Cardimale, G.; Baffoni, C.; Pasquino, A.M.; Bernasconi, S.; Bartolotta, E.; Mucci, M.; Ghigo, E. 1996: Effects of phenylalanine, histidine, and leucine on basal and GHRH-stimulated GH secretion and on PRL, insulin, and glucose levels in short children. Comparison with the effects of arginine Journal of Pediatric Endocrinology and Metabolism: Jpem 9(5): 523-531
Ghigo, E.; Bellone, J.; Mazza, E.; Imperiale, E.; Procopio, M.; Valente, F.; Lala, R.; De Sanctis, C.; Camanni, F. 1990: Arginine potentiates the GHRH- but not the pyridostigmine-induced GH secretion in normal short children. Further evidence for a somatostatin suppressing effect of arginine Clinical Endocrinology 32(6): 763-767
Hanew, K.; Tanaka, A.; Utsumi, A. 1998: Plasma GH responses to GHRH, arginine, L-dopa, pyridostigmine, sequential administrations of GHRH and combine administration of PD and GHRH in Turner's syndrome Journal of Endocrinological Investigation (Testo Stampato) 21(2): 72-77
Hanew, K.; Tanaka, A.; Utsumi, A. 1998: Plasma GH responses to GHRH, arginine, L-dopa, pyridostigmine, sequential administrations of GHRH and combined administration of PD and GHRH in Turner's syndrome Journal of Endocrinological Investigation 21(2): 72-77
Wang, Y.X.; Zhou, T.; Pang, C.C. 1991: Pressor effects of L and D enantiomers of NG-nitro-arginine in conscious rats are antagonized by L- but not D-arginine European Journal of Pharmacology 200(1): 77-81
Bennett, T.; Compton, A.M.; Gardiner, S.M.; Moncada, S.; Palmer, R.M.J. 1990: Effects of l arginine acetate l arg on the hemodynamic actions of n g monomethyl l arginine l nmma in conscious rats Journal of Physiology (Cambridge) 422: 51P
Gardiner, S M.; Compton, A M.; Kemp, P A.; Bennett, T 1991: Hemodynamic Effects of NG-Monomethyl-l-Arginine and NG-Nitro-l-Arginine Methyl Ester in Conscious, Unrestrained Rats Journal of Cardiovascular Pharmacology 17(Suppl 3): S173-S181
